天然低分子物質チミジンの鼻腔から脳への直接移行性 　 -アロマセラピーにおける、もう一つの作用点の可能性について-
川口健夫ほか、Aroma Research 1(2), 53-57（2000）

QOLに対するアロマセラピー効果とその可能性
川口健夫、Aroma Research, 臨時増刊No.1, 89-93 (2001)

アロマセラピーの最前線　 -効果の客観的評価をめざして-
川口健夫、医学のあゆみ、197、551-554（2001）

免疫系・アレルギー疾患とハーブ　 -ハーブ医薬の現状と効果、その安全な使用法（１）-
川口健夫、aromatopia, 64, 32-36（2004）

ハーブの作用とその科学的根拠 -ハーブ医薬の現状と効果、その安全な使用法（2）-
川口健夫、aromatopia, 65, 80-83（2004）

ハーブと医薬品の相互作用 -ハーブ医薬の現状と効果、その安全な使用法（3）-
川口健夫、aromatopia, 66, 77-80（2004）

エッセンシャルオイルの薬理特性とその適正使用
川口健夫、aromatopia, 65, 10-15（2004）

アロマテラピーの血圧および脈拍数への影響 　-126名の健常人ボランティアによる効果判定試験-
川口健夫、Aroma Research,　6、60-63　(2005)

カモミール精油の特徴と効用　- アズレン類の薬理作用に注目して -
川口健夫、aromatopia, 83, 6-9（2007）

ローズウッド精油の特徴とリナロールの薬理作用に注目して　
川口健夫、aromatopia, 84, 12-15（2007）

乳香と没薬の精油の主成分の特徴と効用
川口健夫、aromatopia, 85, 10-12（2007）

ジュニパー精油の主成分の特徴と効用について
川口健夫、aromatopia, 87, 6-7（2008）

月桃精油の主成分とその特徴
川口健夫、aromatopia, 88, 8-9（2008）

ゼラニウム精油の主成分とその特徴
川口健夫、aromatopia, 89, 10-11（2008）

グレープフルーツ精油の主成分とその特徴
川口健夫、aromatopia, 90, 10-11（2008）

エッセンシャルオイルとキャリアーオイルの品質と安全性
川口健夫、aromatopia, 91, 38-42（2008）

ローズマリー精油（3つのケモタイプ、カンファー、シネオール、ベルベノン） の主要成分とその機能性
川口健夫、aromatopia, 92, 8-9（2009）

レモングラスの主成分の特徴とその機能性
川口健夫、aromatopia, 94, 8-9（2009）

ネロリの主成分の特徴とその機能性
川口健夫、aromatopia, 95, 8-9（2009）

ジンジャー精油の主要成分とその機能性
川口健夫、aromatopia, 99, 10-11（2010）

パルマローザ精油と塩酸テルビナフィンを用いた足浴による足白癬治療の試み
服部尚子、井上重治、高橋美貴、内田勝久、川口健夫、安倍茂、Japanese Journal of Aromatherapy, 10, 17-24 (2010)

5

1.Antitumor Activity of 3',5'-Diesters of 5-Fluoro-2'-deoxyuridine Against Murine Leukemia L1210 Cells.
Fumihiko Kanzawa, Akio Hoshi, Kazuo Kuretani, Mineo Saneyoshi, Takeo Kawaguchi. Cancer Chemother. Pharmacol., 6, 19-23, 1981.

2.Release Profiles of 5-Fluorouracil and Its Derivatives from Polycarbonate Matrices in vitro.
Takeo Kawaguchi, Masahiro Nakano, Kazuhiko Juni, Shohei Inoue, Yasuhiko Yoshida. Chem. Pharm. Bull., 30, 1517-1520, 1982.

3.Examination of Biodegradability of Poly(ethylene carbonate) and Poly(propylene carbonate) in the Peritoneal Cavity in Rats.
Takeo Kawaguchi, Masahiro Nakano, Kazuhiko Juni, Shohei Inoue, Yasuhiko Yoshida. Chem. Pharm. Bull., 31, 1400-1403, 1983.

4.Plasma Levels of Tegafur Following Implantation of Polycarbonate Pellets Containing Tegafur or FD-1 into Rats.
Takeo Kawaguchi, Masahiro Nakano, Kazuhiko Juni, Shohei Inoue, Yasuhiko Yoshida. Chem. Pharm. Bull., 31, 4157-4160, 1983.

5.Activity of Esterase in the Hydrolysis of 3',5'-Diesters of 5-Fluoro-2'-deoxyuridine in Relation to the Structure of the Diester Prodrugs.
Takeo Kawaguchi, Yoshiki Suzuki, Yoko Nakahara, Naoki Nambu, Tsuneji Nagai. Chem. Pharm. Bull., 33, 301-307, 1985.

6.Specificity of Esterases and Structure of Prodrug Esters. II. Hydrolytic Regeneration Behavior of 5-Fluoro-2'-deoxyuridine (FUdR) from 3',5'-Diesters of FUdR with Rat Tissue Homogenates and Plasma in Relation to Their Antitumor Activity.
Takeo Kawaguchi, Yoshiki Suzuki, Naoki Nambu, Tsuneji Nagai. Chem. Pharm. Bull., 33, 1652-1659, 1985.

7.Specificity of Esterases and Structure of Prodrug Esters. III. Activity of Rat Tissue Homogenates, Rat Plasma, and Porcine Liver Esterase in Hydrolysis of 3',5'-Bisdicarboxylic-hemiesters of 5-Fluoro-2'-deoxyuridine.
Takeo Kawaguchi, Yoshiki Suzuki, Naoki Nambu, Tsuneji Nagai. Chem. Pharm. Bull., 33, 2956-2961, 1985.

8.Potentiation by Acyclothymidine Esters of the Antitumor Effect of Orally Administered 5-Fluoro-2'-deoxyuridine Esters on L1210 in Mice.
Takeo Kawaguchi, Masahiko Saito, Mineo Saneyoshi. Jpn. J. Cancer Res. (Gann), 77, 436-439, 1986.

9.Dehydration and Epimerization of 7-Thiaprostaglandin-E1 Analogues.
Takeo Kawaguchi and Yoshiki Suzuki. J. Pharm. Sci., 75, 992-994, 1986.

10.Selective Antitumor Effects of 3',5'-Dioctanoyl-5-fluoro-2'- deoxyuridine, a Lipophilic Prodrug of 5-Fluoro-2'-deoxyuridine, Dissolved in an Oily Lymphographic Agent on Hepatic Cancer of Rabbits Bearing VX-2 Tumor.
Shoji Fukushima, Takeo Kawaguchi, Mika Nishida, Kazuhiko Juni, Yasuyuki Yamashita, Mutsumasa Takahashi, Masahiro Nakano.
Cancer Res., 47, 1390-1394, 1987.

11.In Vitro Drug Release from Macromolecule-Drug Conjugates of 3'-(7-Carboxyheptanoyl)-5-fluoro-2'-deoxyuridine with Decylenediamine- dextran T70 of Poly-L-lysine.
Hiraku Onishi, Takeo Kawaguchi, Tsuneji Nagai Chem. Pharm. Bull., 35, 3370-3374, 1987.

12.Inhibition of Phosphorolytic Degradation of 5-Fluoro-2'- deoxyuridine by Pyrimidine Acyclonucleosides and Normal Pyrimidine Metabolites in Rat and Beagle Tissue Homogenates.
Takeo Kawaguchi and Mineo Saneyoshi. Chem. Pharm. Bull., 36, 1899-1901, 1988.

13.5-FU系抗癌薬：リピオドール製剤からの薬物徐放性に関する検討．
川口　健夫、金澤　あずさ、高山　幸三、町田　良治、永井　恒司． 癌と化学療法, 15, 1995-1997, 1988.

14.Selective Accumulatiopn of 3',5'-Dioctanoyl-5-fluoro-2'-deoxy- uridine (FdUrd-C8) and Sustained Release of Its Active Metabolites in VX-2 Rabbit Hepatoma following Intraarterial Administration of FdUrd-C8 Solution in Lipiodol.
Takeo Kawaguchi, Shoji Fukushima, Yoshiki Hayashi, Mika Kaneda, Masahiro Nakano. Cancer Res., 48, 4179-4183, 1988.

15.Non-enzymatic and Enzymatic Hydrolysis of 5-fluoro-2'- deoxyuridine (FUdR) Esters: Specificity to the Structure and the Site of Esterification.
Takeo Kawaguchi, Shoji Fukushima, Yoshiki Hayashi, Masahiro Nakano. Pharm. Res., 5, 741-744, 1988.

16.Specificity of Esterases and Structure of Prodrug Esters (II): Reactivity of Verious Acylated Acetaminophen Compounds and Acetylaminobenzoated Compounds.
Hiromitsu Seki, Takeo Kawaguchi, Takeru Higuchi. J. Pharm. Sci., 77, 855-860, 1988.

17.Potentiation of the Antitumor Effect of 5-Fluoro-2'-deoxyuridine Esters on L1210 in Mice Combination with Acyclothymidine Esters via Oral Administration.
Takeo Kawaguchi, Masahiko Saito, Mineo Saneyoshi. J. Pharm. Sci., 77, 939-943, 1988.

18.Application of New Silicone Gel to Suatained Release Dosage Form of Antitumor Drug.
Kazumichi Imasaka, Haruhisa Ueda, Tadashi Azuma, Takeo Kawaguchi, Tsuneji Nagai. Drug Design and Delivery, 4, 237-246, 1989.

19.Enzymatic and Chemical Stability of 2',3'-Dideoxy-2',3'-didehydropyrimidine Nucleosides: Potential Anti-AIDS Agents.
Takeo Kawaguchi, Shoji Fukushima, Masayo Ohmura, Motohiro Mishima, Masahiro Nakano. Chem. Pharm. Bull., 37, 1944-1945, 1989.

20.Studies on 2',3'-Dideoxy-2',3'-didehydropyrimidine Nucleosides. II. N4-Benzoyl-2',3'-dideoxy-2',3'-didehydrocytidine as a prodrug of 2',3'-Dideoxy-2',3'-didehydrocytidine (DDCN).
Takeo Kawaguchi, Kozo Ishikawa, Toshinobu Seki, Kazuhiko Juni, Shoji Fukushima, Masahiro Nakano Chem. Pharm. Bull., 37, 2547-2549, 1989.

21.Hydrolysis of 3',5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in Rabbit and Human Plasma and Its Release from Oily Solution.
Shoji Fukushima, Yoshiki Hayashi, Takeo Kawaguchi, Mika Kaneko, Masahiro Nakano. J. Pharmacobio-Dyn., 12, 495-502, 1989.

22.Percutaneous Absorption of Azidothymidine in Rats.
Toshinobu Seki, Takeo Kawaguchi, Kenji Sugibayashi, Kazuhiko Juni, Yasunori Morimoto. Int. J. Pharmaceut., 57, 73-75, 1989.

23.Intraarterial Infusion of 5-Fluoro-2'-deoxyuridine-C8 Dissolved in a Lymphographic Agent in Malignant Liver Tumors.
Yasuyuki Yamashita, Mutsumasa Takahashi, Hiromasa Bussaka, Shoji Fukushima, Takeo Kawaguchi, Masahiro Nakano. Cancer, 64, 2437-2444, 1989.

24.Ester Prodrugs of 2',3'-Dideoxy-2',3'-didehydrothymidine (D4T).
Takeo Kawaguchi, Tetsuya Hasegawa, Toshinobu Seki, Kazuhiko Juni, Mineo Saneyoshi. Int. J. Pharmaceut., 58, R1-3, 1990.

25.Ester Prodrugs of Zidovudine.
Takeo Kawaguchi, Kozo Ishikawa, Toshinobu Seki, Kazuhiko Juni. J. Pharm. Sci., 79, 531-533, 1990.

26.Membrane PermeationーControlled Transdermal Delivery System Design． Influence of Controlling Membrane and Adhesive on Skin Permeation of Isosorbide Dinitrate.
Toshinobu Seki, Takeo Kawaguchi, Kenji Sugibayashi, Kazuhiko Juni, Yasunori Morimoto. Chem. Pharm. Bull., 38, 740-743, 1990.

27.Controlled Release of 3',5'-Diester Prodrug of 5-Fluoro-2'- deoxyuridine from Poly-L-lactic Acid Microspheres.
Toshinobu Seki, Takeo Kawaguchi, Hirotaka Endo, Kazuhiko Juni, Masahiro Nakano. J. Pharm. Sci., 79, 985-987, 1990.

28.Enhanced Delivery of Zidovudine through Rat and Human Skin via Ester Prodrugs.
Toshinobu Seki, Takeo Kawaguchi, Kazuhiko Juni. Pharm. Res., 7, 948-952, 1990.

29.Enhanced Transdermal Delivery of Zidovudine in Rats and Human Skin.
Toshinobu Seki, Takeo Kawaguchi, Kazuhiko Juni, Kenji Sugibayashi, Yasunori Morimoto. Chem. Pharm. Bull., 38, 3086-3089, 1990.

30.全身作用を目的とするzidovudine経皮吸収製剤の開発に関する基礎検討．
川口　健夫、関　俊暢、従二　和彦． Chemotherapy, 38, 897-901, 1990.

31.埋込型徐放性製剤の基剤であるPHYCON 6600の薬剤学的特性．
今坂　一道、上田　晴久、東都　正、川口　健夫、永井　恒司．薬剤学、50,　256-262,　1990．

32.Plasma Concentration of Zidovudine in Rats via Oral Administration of Its Ester Prodrugs.
Takeo Kawaguchi, Hirotaka Endo, Toshinobu Seki, Kazuhiko Juni. J. Pharm. Sci., 80, 404-405, 1991.

33.抗レトロウイルス薬2',3'-didehydro-3'-deoxythymidine (D4T)およびそのエステルプロドラッグの経皮吸収性．
川口　健夫、長谷川　哲也、遠藤　浩孝、関　俊暢、従二　和彦．実吉　峯郎． Drug Delivery System, 6, 57-60, 1991.

34.Controlled Release of 5-Fluoro-2'-deoxyuridine by the Combination of Prodrug and Polymer Matrix.
Hirotaka Endo, Takeo Kawaguchi, Toshinobu Seki, Tetsuya Hasegawa, Kazuhiko Juni. Chem. Pharm. Bull., 39, 458-464, 1991.

35.Sustained Transdermal Delivery of Zidovudine via Controlled Release of Penetration Enhancer.
Toshinobu Seki, Takeo Kawaguchi, Kazuhiko Juni, Kenji Sugibayashi, Yasunori Morimoto. J. Contro. Rel., 17, 41-48, 1991.

36.Rectal Absorption of Zidovudine.
Takeo Kawaguchi, Tetsuya Hasegawa, Kazuhiko Juni, Toshinobu Seki. Int. J. Pharmaceut., 77, 71-74, 1991.

37.Control of Drug Release Using a Combination of Prodrug and Polymer Matrix.
Takeo Kawaguchi, Akiko Tsugane, Kumiko Higashide, Hirotaka Endo, Tetsuya Hasegawa, Hiromi Kanno, Toshinobu Seki, Kazuhiko Juni, Shouji Fukushima, Masahiro Nakano. J. Pharm. Sci., 81, 508-512, 1992.

38.Prodrugs of 2',3'-Dideoxyinosine (DDI): Improved Oral Bioavailability via Hydrophobic Esters.
Takeo Kawaguchi, Tetsuya Hasegawa, Toshinobu Seki, Kazuhiko Juni, Yasunori Morimoto, Akira Miyakawa, Mineo Saneyoshi.
Chem. Pharm. Bull., 40, 1338-1340, 1992.

39.Anticancer Effect of Free Polyunsaturated Fatty Acids in an Oily Lymphographic Agent following Intrahepatic Arterial Administration to a Rabbit Bearing VX-2 Tumor.
Yoshiki Hayashi, Shoji Fukushima, Shuichi Kishimoto, Takeo Kawaguchi, Mitsuhiro Numata, Yoshihiro Isoda, Jiro Hirano, Masahiro Nakano.
Cancer Res., 52, 400-405, 1992.

40.抗エイズ薬2',3'-ジデオキシイノシン(DDI)プロドラッグの合成と油性基剤を用いた経口投与後の血中濃度推移．
川口　健夫、長谷川　哲也、関　俊暢、従二　和彦、森本　雍憲、宮川　晃、　実吉　峯郎． Drug Delivery System, 7, 203-207, 1992.

41.エチレン-酢酸ビニル共重合体マイクロスフィアからの5-フルオロ-2'-デオキシウリジンの3',5'-ジエステルプロドラッグの放出．
関　俊暢、細田　和代、遠藤　浩孝、川口　健夫、従二　和彦．薬剤学、52,　152-159,　1992.

42.Prodrugs of 2',3'-Didehydro-2'-deoxythymidine (D4T).
Tetsuya Hasegawa, Toshinobu Seki, Kazuhiko Juni, Mineo Saneyoshi, Takeo Kawaguchi. J. Pharm. Sci., 82, 1232-1236, 1993.

43.Permeation of Paraquat through Cellulose Membrane in the Presence of Cation Exchange Resins.
Hiraku Machijima, Toshinobu Seki, Takeo Kawaguchi. Yakuzaigaku, 53, 130-134, 1993.

44.Differential Effects of Acyclothymidine, a Potent Pyrimidine Nucleoside Phosphorylase Inhibitor, on the Pharmacokinetics of Doxifluridine in Rabbits via Oral Administration.
Akinobu Hamada, Shoji Fukushima, Aya Morinaga, Mineo Saneyoshi, Takeo Kawaguchi, Masahiro Nakano. Biol. Pharm. Bull., 16, 1297-1300, 1993.

45.Evaluation of a New Lipophilic Prodrug 3',5'-Dioctanoyl-5- bromodeoxyuridine (BrdU-C8) Suspended in Lipiodol as a Radiosensitizer for the Treatment of AH136B Tumor.
hitoshi Ohara, Toru Beppu, Yasuo Yamaguchi, Yoshihiro Masuda, Shoji Fukushima, Takeo Kawaguchi, Michio Ogawa. Anticancer Res., 13, 655-660, 1993.

46. Novel Stabilizing Method for Antisense Oligodeoxynucleotide.
Toshihiko Sueishi, Toshinobu Seki, Kazuhiko Juni, Tetsuya Hasegawa, Mineo Saneyoshi, Takeo Kawaguchi. Pharm. Res., 11, 455-457, 1994.

47.シスプラチン含有多相エマルジョンの腎毒性に関する研究．
金　一、川口　健夫、従二　和彦、李　鳳龍．Drug Delivery System, 9, 39-43, 1994.

48.Nasal Absorption of Zidovudine and Its Transport to Cerebrospinal Fluid in Rats.
Toshinobu Seki, Norihito Sato, Tetsuya Hasegawa, Takeo Kawaguchi, Kazuhiko Juni. Biol. Pharm. Bull., 17, 1135-1137, 1994.

49.修飾型センスと天然型アンチセンスからなる二本鎖オリゴデオキシヌクレオチドの安定性と体内動態.
川口　健夫、浅川　浩樹、従二　和彦、末石　俊彦、太田　尚志、実吉　峯郎．Drug Delivery System, 9, 407-411, 1994.

50.Stability, Specific Binding Activity, and Plasma Concentration in Mice of an Oligodeoxynucleotide Modified at 5'-Terminal with Poly(ethylene glycol).
Takeo Kawaguchi, Hiroki Asakawa, Yasutaka Tashiro, Kazuhiko Juni, Toshihiko Sueishi. Biol. Pharm. Bull., 18, 474-476, 1995.

51.Sytnthesis and Antileukemic Activity of Chymotrypsin-activated Derivatives of 3'-Amino-2',3'-dideoxycytidine.
Takeo Kawaguchi, Hiroshi Sakairi, Shigeru Kimura, Toyofumi Yamaguchi, Mineo Saneyoshi. Chem. Pharm. Bull., 43, 501-504, 1995.

52.Synthesis and Investigation of N4-Substituted Cytarabine Derivatives as Prodrugs.
Tarek A. Fadl, Tetsuya Hasegawa, Adel F. Youssef, Hassan H. Farag, Fargahly A. Omar, Takeo Kawaguchi. Pharmazie, 50, 382-387, 1995.

53.Inhibition of 5'-Deoxy-5-fluorouridine Phosphorolysis by Acyclopyrimidinenucleosides in Intestinal Tissue Homogenates.
Akinobu Hamada, Shoji Fukushima, Mineo Saneyoshi,Kawaguchi, Masahiro Nakano. Biol. Pharm. Bull., 18, 172-175, 1995.

54.Intestinal Absorption and First-pass Elimination of 2',3'-Dideoxynucleosides Following Oral Administration in Rats.
Tetsuya Hasegawa, Kazuhiko Juni, Mineo Saneyoshi, Takeo Kawaguchi. Biol. Pharm. Bull., 19, 599-603, 1996.

55.Modulation of the Pharmacokinetics of 5'-Deoxy-5-fluorouridine and 5-Fluorouracil in Rats by Oral Co-administration of Acyclothymidine.
Akinobu Hamada, Shoji Fukushima, Mineo Saneyoshi, Satoshi Shimizu, Takeo Kawaguchi, Masahiro Nakano. Biol. Pharm. Bull., 19, 729-732, 1996.

56.Metabolism of Testosterone and Its Ester Derivatives in Organotypic Coculture of Human Dermal Fibroblasts with Differentiated Epidermis.
Tarek A. Fadl, Tetsuya Hasegawa, Adel F. Youssef, Hassan H. Farag, Fargahly A. Omar, Takeo Kawaguchi. Pharmazie, 50, 382-387, 1995.

57.Permeation of Zidovudine and Probenecid from Oily Bases Containing Alcohols through Rat Skin.
Yi Jin, Chiyoko Toeda, Toshinobu Seki, Takeo Kawaguchi, Kazuhiko Juni. Drug Develop. Ind. Pharm., 22, 653-658, 1996.

58.Nasal Absorption of 2',3'-Didehydro-3'-deoxythymidine (D4T) and Its Esters in Rats.
Toshiyuki Yajima, Tetsuya Hasegawa, Kazuhiko Juni, Mineo Saneyoshi, Takeo Kawaguchi. Biol. Pharm. Bull., 19, 1234-1237, 1996.

59.Antisense Oligodeoxynucleotides Bearing 5-Phenylethyl-2'- deoxyuridylate at 3'-terminus: Exonuclease-resistant Molecule with Natural Phosphodiester Backbone.
Takeo Kawaguchi, Toyofumi Yamaguchi, Satoshi Tanaka, Yasutaka Tashiro, Mineo Saneyoshi. J. Pharm. Sci., 85, 815-818, 1996.

60.Acyclothymidine Alleviates Intestinal Toxicity of 5'-Deoxy-5- fluorouridine without loss of Antitumor Activity in Mice.
Akinobu Hamada, Shoji Fukushima, Mineo Saneyoshi, Satoshi Shimizu, Takeo Kawaguchi, Masahiro Nakano. Biol. Pharm. Bull., 19, 1362-1366, 1996.

61.Steric parameters in PLE Catalyzed Hydrolysis of N4-Substituted Cytarabine Ester Prodrugs.
Takeo Kawaguchi, Adel F. Youssef, Tarek A. Fadl, Fargahly A. Omar, Hassan H. Farag, Tetsuya Hasegawa. Pharmazie, 51, 717-719, 1996.

62.アポトーシス回避を指標としたアンチセンス効果の選択的評価方法
田代　康壽貴、山口　十四文、実吉　峯郎、綿矢　有佑、長谷川　哲也、　　川口　健夫． Drug Delivery System, 12, 39-42, 1997.

63.Inhibition of 5'-Deoxy-5-fluorouridine Phosphorolysis by Acyclo- thymidine in Tumor Cell Homogenates.
Akinobu Hamada, Masahiro Nakano, Satoshi Simizu, Tetsuya Hasegawa, Takeo Kawaguchi. Biol. Pharm. Bull., 20, 935-938, 1997.

64.The Effect of Several Penetration-Enhancer on the Simultaneous Transport and Metabolism of Ethyl Nicotinate in Hairless Rat Skin.
Teruaki Hayashi, Yumiko Iida, Tomio Hatanaka, Takeo Kawaguchi, Kenji Sugibayashi, Yasunori Morimoto. Int. J. Pharmaceut., 154, 141-148, 1997.

65.Chiral Discrimination of 2'-Deoxy-L-cytidine and L-Nucleotides by Mouse Deoxycytidine Kinase: Low Stereospecificities for Substrate and Effectors.
Aki Tomikawa, Satoru Kohgo, Hidenori Ikezawa, Naoko Iwanami, Koichi Shudo, Takeo Kawaguchi, Mineo Saneyoshi, Toyofumi Yamaguchi.
Biochem. Biophys. Res. Comm., 239, 329-333, 1997.

66.Direct Transport of 2',3'-Didehydro-3'-deoxythymidine (D4T) and Its Ester Derivatives to the Cerebrospinal Fluid via the Nasal Mucous Membrane in Rats.
Toshiyuki Yajima, Kazuhiko Juni, Mineo Saneyoshi, Tetsuya Haswgawa, Takeo Kawaguchi. Biol. Pharm. Bull., 21, 272-277, 1998.

67.Synthetic Nucleosides and Nucleotides. 40. Selective Inhibition of Eukaryotic DNA Polymerase α by 9-(β -D-Arabinofuranosyl)-2-(p-n-Butylanilino)Adenine 5'-Triphosphate (BuAaraATP) and Its 2'-up Azido Analog：Synthesis and Enzymatic Evaluations.
Aki Tomikawa, Masaki Seno, Kunie Sato-Kiyotaki, Chizuru Ohtsuki, Toshiaki Hirai, Toyofumi Yamaguchi, Takeo Kawaguchi, Shonen Yoshida, Mineo Saneyoshi. Nucleosides and Nucleotides, 17, 487-501, 1998.

68.Thymidineの鼻粘膜透過に関する研究
矢島敏行、長谷川哲也、従二和彦、実吉峯郎、川口健夫 Drug Delivery System, 13, 179-184, 1998.

69.Cytotoxicity and Pharmacokinetics of 1-β-D-Arabinofuranosyl- 2-thiocytosine, a 2-Sulphur Substituted Derivative of Cytarabine.
Takeo Kawaguchi, Tomohisa Ichikawa, Tetsuya Hasegawa, Mineo Saneyoshi, Ayako Yukita, Makoto Asano, Toshiyuki Wakayama, Hisatoyo Kato, Toshiyuki Nagata. Biol.Pharm.Bull., 22, 100-102, 1999

70.Relationship between Solubility of Chitosan in Alcoholic Solution and Its Gelation.
Motohiko Sano, Osamu Hosoya, Shose Taoka, Toshinobu Seki, Takeo Kawaguchi, Kenji Sugibayashi, Kazuhiko Juni, Yasunori Morimoto.
Chem.Pharm.Bull., 47, 1044-1046, 1999

71.Enzymatic Reactivity and Anti-tumor Activity of 1-(β-D- Arabinofuranosyl)-2-thiocytosine Derivertives.
Takeo Kawaguchi, Tomohisa Ichikawa, Tetsuya Hasegawa, Mineo Saneyoshi, Toshiyuki Wakayama, Hisatoyo Kato, Ayako Yukita, Toshiyuki Nagata. Chem.Pharm.Bull., 48, 454-457, 2000

72.Effect of Temperature on Drug Release from Copoly(L-Lactic Acid/δ-Valeralactone) Microspheres.
Hirotaka Endoh, Yasuo Hagita, Toshinobu Seki, Takeo Kawaguchi, Kazuhiko Juni.J.Pharm.Sci.Technol.,Jpn., 60, 119-127, 2000

73.天然低分子物質チミジンの鼻腔から脳への直接移行性　-アロマセラピーにおける、もう一つの作用点の可能性について-
川口健夫、矢島敏行、長谷川哲也、中野眞汎、濱田哲暢 Aroma Research 1(2), 53-57,2000

74.Roles of Hydrophobicity, Protein Binding and the Probenicid-Sensitive Transport System in the Cerebrospinal Fluid Delivery of Nucleoside Analogues with Anti-viral Activity.
akeo Kawaguchi, Masaki Kusumi, Tetsuya Hasegawa, Toshiyuki Nagata, Mineo Saneyoshi, Masahiro Nakano, Akinobu Hamada
Biol.Pharm.Bull., 23,979-983,2000

75.QOLに対するアロマセラピー効果とその可能性
川口　健夫 Aroma Research 　Supp.(1), 89-93,2001

76.Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells.
Nobuaki Shiraki, Keiko Okamura, Jin Tokunaga, Takafumi Ohmura, Kazuto Yasuda, Takeo Kawaguchi, Akinobu Hamada, Masahiro Nakano
Jpn.J.Cancer Res., 93,209-215,2002

77.アロマテラピーの血圧および脈拍数への影響　 -　126名の健常人ボランティアによる効果判定試験　-
川口健夫、Aroma Research,　6、60-63,　2005

78.パルマローザ精油と塩酸テルビナフィンを用いた足浴による足白癬治療の試み
服部尚子、井上重治、高橋美貴、内田勝久、川口健夫、安倍茂、 Japanese Journal of Aromatherapy,　10, 17-24 , 2010